Brain inflammation as a biomarker in epilepsy

MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy

Epilepsy is a chronic clinical syndrome of brain function which is caused by abnormal discharge of neurons. MicroRNAs (MiRNAs) are small noncoding RNAs which act post transcriptionally to regulate negatively protein levels. They affect neuroinflammatory signaling, glial and neuronal structure and function, neurogenesis, cell death, and other processes linked to epileptogenesis. The aim of this ...

Epilepsy and brain inflammation.

During the last decade, experimental research has demonstrated a prominent role of glial cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and recurrence. In particular, alterations in the phenotype and function of activated astrocytes and microglial cells have been described in experimental and human epileptic tissue, including modifications in potassium...

Periostin as a biomarker of airway inflammation.

Plasma gelsolin as a biomarker of inflammation

The prognostic implications of declining plasma gelsolin levels have been documented after a diverse variety of acute insults. Because gelsolin concentrations fall prior to the development of complications, a pathophysiological role for gelsolin depletion has been postulated in delayed multiorgan failure. The original hypothesis about the function of circulating gelsolin was that it scavenged a...

Glycine as a biomarker in brain tumors

Introduction− Glycine is a major inhibitory neurotransmitter in the mammalian central nervous system [1]. High levels of glycine have been detected in the brain of patients with hyperglycinemia and in brain tumors in particular glioblastoma multiforme (GBM) [2-4]. Given its significance, an accurate measure of brain glycine is desirable; this is hindered by the fact that its resonance overlaps ...